Spider-Man has faces a lot of the classic Halloween & Hollywood monsters like Dracula, Wolf Man, and even Frankenstein. He's had his run-ins with modern monsters made just for Marvel Comics like Morbius. He's also teamed up with vampire hunters like Blade who has had three movies and one failed TV series not to mention his appearances on the Fox Spider-Man animated series.

Spider-Man vs the Wolfman
Well specifically Marvel's version of the Wolf Man the Werewolf by Night

Blade vs Spider-Man
Get history on the vampire hunter and his run ins with Spider-Man.

Spider-Man VS Dracula
Did the Hollywood legendary vampire Dracula take a bite out of Spider-Man?

Spider-Man VS Morbius
So what's worse a vampire made of science of superstition?

Spider-Man vs Frankenstein
Marvel comics version of the classic monster teams up with Spider-Man